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dc.contributor Brown, Heather en_US
dc.contributor Landerholm, Thomas E. en_US
dc.contributor.advisor Crawford, Robert en_US
dc.contributor.author Milani, Anthony Patrick
dc.date.accessioned 2017-12-12T19:12:33Z
dc.date.available 2017-12-12T19:12:33Z
dc.date.issued 2017-12-12
dc.date.submitted 2017-11-30
dc.identifier.uri http://hdl.handle.net/10211.3/198841 en
dc.description Project (M.S., Biological Sciences)--California State University, Sacramento, 2017. en_US
dc.description.abstract The endolysosomal system has recently come under heavy scrutiny as a potentially major contributor to the progression of late-onset neurodegenerative diseases. In this review, I highlight our current understanding of the endolysosomal system, and the Rab GTPase cascade regulating significant portions of its normal progression. Dysfunction in this cascade potentially accounts for many well-documented cellular phenotypes pertaining to neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. Despite extensive study, many of the molecular mechanisms underlying the progression of late-onset neurodegenerative diseases remain elusive. The use of systems biology approaches appears to be the most promising route forward for understanding the etiologies of the systemic disorder observed in these diseases, which are likely to be highly variable between individuals. en_US
dc.description.sponsorship Biological Sciences en_US
dc.language.iso en_US en_US
dc.subject Rab GTPase en_US
dc.subject Alzheimer's disease en_US
dc.subject Parkinson's disease en_US
dc.subject Early endosome en_US
dc.subject Lysosome en_US
dc.subject Endolysosomal system en_US
dc.title A systems biology roadmap to understanding late-onset neurodegenerative disease en_US
dc.type Project en_US

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